ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Sublingual Immunotherapy
Dr. Nerin N. BAHÇECİLER,a Dr. Cevdet ÖZDEMİR,a Dr. Işıl B. BARLANa
aPediatrik Allerji-İmmünoloji BD, Marmara Üniversitesi Tıp Fakültesi, İSTANBUL
While safety and efficacy of specific immunotherapy (SIT) by the sublingual route in patients with allergic asthma/rhinitis symptoms have now been largely documented, the long term efficacy and impact on natural history of allergic diseases warrants further investigation. Meanwhile, the immunological mechanisms have only started to be investigated. It seems likely that the contact of the allergen with the oral mucosa is a critical determinant of the subsequent T cell response. Most likely, the allergen captured within the oral mucosa by Langerhans-like dendritic cells, subsequently mature and migrate to proximal draining lymph nodes, which then induce T lymphocytes. Animal experiments point to enhanced expansion of TGF-β, IL-10 and Fox p3 mRNA in CD4+ T cells, indicators of tolerance, induced by mucosal vaccination. Meanwhile, although there is still no firm proof in human, data on increase in allergen-induced IL-10 and allergen-specific IgA secretion supports the possible role of T regulatory cells in sublingual immunotherapy.Keywords: Desensitization, immunologic; asthmaTurkiye Klinikleri J Int Med Sci 2007, 3(41):30-35
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