ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Mechanisms Of Allergen-specific Immunotherapy
Dr. Ali KOKULUDAĞa
aİmmünoloji-Alerji BD, Ege Üniversitesi Tıp Fakültesi, İZMİR
Specific immunotherapy (SIT) has been used for almost a century for allergic rhinitis, allergic asthma and venom allergy. SIT is the only treatment able to modify the natural history of the allergic diseases. There are many clinical trials which show SIT to be an effective treatment in the management of allergic diseases, but its mechanism of action is still not clearly understood. SIT inhibits the early and late nasal, bronchial, and cutaneous responses to allergen challenge. An increase of allergen-specific IgG4 and a decrease of IgE appear after SIT. Successful SIT is associated with a decrease in the number of mast cells and eosinophils, as well as a decrease in the release of mediators. High-dose allergen exposure during SIT results in both immune deviation of Th2 responses in favor of Th0/Th1 response and in the generation of IL-10 and TGF-beta producing CD4+CD25+ Treg cells.Keywords: Allergy, specific immunotherapy, T-regulatory cellsTurkiye Klinikleri J Int Med Sci 2007, 3(41):8-13
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